Trifluoroacetic acid → (S)-2-amino-N-(2-hydroxyethyl)-3,3-dimethylbutanamide

HRID 1623998Notes

Reaction equation

HRID 1623998 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5](=[O:19])[C@@H:6]([NH:11]C(=O)OC(C)(C)C)[C:7]([CH3:10])([CH3:9])[CH3:8].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:11][C@@H:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:5]([NH:4][CH2:3][CH2:2][OH:1])=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86669709HCID 86669709, compound

Product 1

HCID 58124726(S)-2-amino-N-(2-hydroxyethyl)-3,3-dimethylbutanamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-tert-Butyl 1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate was treated overnight with trifluoroacetic acid in methylene chloride. The solution was concentrated to give the title compound without further purification.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-320baf1d015d45ae8c2be42b4e790944
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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