1,2-Dibromoethane → HCID 178505629, compound

HRID 1624460Notes

Reaction equation

HRID 1624460 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][Br:5].[Zn:10].BrCCBr>C1COCC1>[Br-:5].[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][Zn+:10]

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 23994ZincHCID 67968alpha-Bromo-o-fluorotoluene

Product 1

HCID 178505629HCID 178505629, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Fluoro-benzyl bromide (1 g, 5.29 mmol), zinc (0.380 g, 5.82 mmol) and 1,2-dibromoethane (0.050 mL, 0.58 mmol) were mixed in THF (10 ML) and heated to reflux overnight. After cooling a solution of the title compound was obtained that was used directly and immediately in the next step.

Workup

  1. temperatureheated
  2. temperatureto reflux overnight

Sources & evidence

ORD record
ord-158b6badf40d48f3b6629f02307e00c8
Source dataset
uspto-grants-2014_07
Patent number
US08778983B2

Reaction notes

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