Hydrochloric Acid → HCID 24804226, compound

HRID 1624990Notes

Reaction equation

HRID 1624990 reaction equation
[CH:1]1([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][N:16]([CH2:23][CH:24]4[CH2:28][O:27]C(C)(C)[O:25]4)[C:17](=[O:22])[C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.C(Cl)Cl>CCOCC>[CH:1]1([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][N:16]([CH2:23][CH:24]([OH:25])[CH2:28][OH:27])[C:17](=[O:22])[C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 24804064HCID 24804064, compound

Product 1

HCID 24804226HCID 24804226, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

N-(Cycloheptylmethyl)-2-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1-oxo-1,2-dihydroisoquinoline-5-carboxamide (110 mg, 0.00028 mol), hydrogen chloride (5 mL, 0.006 mol) as 2M solution in ether and methylene chloride (5 mL, 0.08 mol) were stirred at room temperature for 2 hours. The volatiles were removed under vacuum, the residue was purified via flash chromatography (12 g of silica gel, 0-10% MeOH/CH2Cl2) to give a white solid.

Workup

  1. customThe volatiles were removed under vacuum
  2. customthe residue was purified via flash chromatography (12 g of silica gel, 0-10% MeOH/CH2Cl2)
  3. customto give a white solid

Sources & evidence

ORD record
ord-dfebe55bd22b421ca74830cd3a0c13de
Source dataset
uspto-grants-2014_07
Patent number
US08779144B2

Reaction notes

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