Methanol → HCID 24804889, compound

HRID 1625005Notes

Reaction equation

HRID 1625005 reaction equation
C([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[C:18](=[O:28])[NH:19][CH2:20][CH:21]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[C:9]1=[O:29])[CH3:7])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>>[CH:21]1([CH2:20][NH:19][C:18]([C:14]2[C:15]3[CH:16]=[CH:17][N:8]([C@H:6]([CH3:7])[CH2:5][OH:4])[C:9](=[O:29])[C:10]=3[CH:11]=[CH:12][CH:13]=2)=[O:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 67204025HCID 67204025, compound

Product 1

HCID 24804889HCID 24804889, compound

Procedure

(R)-2-(5-(Cycloheptylmethylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propyl acetate (170 mg, 0.00043 mol) and Potassium carbonate (100 mg, 0.0008 mol) were stirred in methanol (5 mL, 0.1 mol) at room temperature overnight. The volatiles were removed under vacuo and the residue was purified via flash chromatography (12 g of silica gel, 0-10% MeOH/CH2Cl2) to give a white solid.

Workup

  1. customThe volatiles were removed under vacuo
  2. customthe residue was purified via flash chromatography (12 g of silica gel, 0-10% MeOH/CH2Cl2)
  3. customto give a white solid

Sources & evidence

ORD record
ord-441c5ddbca7b4fcf8d058967cc72bb1c
Source dataset
uspto-grants-2014_07
Patent number
US08779144B2

Reaction notes

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