Trifluoroacetic acid → HCID 68606710, compound

HRID 1625443Notes

Reaction equation

HRID 1625443 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:10]=[C:11]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:26]([C:28]4[C:29](=[O:43])[N:30]([CH2:34][C:35]5[CH:40]=[CH:39][C:38]([F:41])=[C:37]([F:42])[CH:36]=5)[CH:31]=[CH:32][CH:33]=4)=[O:27])[CH:19]=3)=[CH:16][N:15]([S:44]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)(=[O:46])=[O:45])[C:12]2=[N:13][CH:14]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:10]=[C:11]2[C:17]([C:18]3[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=3)[CH2:24][NH:25][C:26]([C:28]3[C:29](=[O:43])[N:30]([CH2:34][C:35]4[CH:40]=[CH:39][C:38]([F:41])=[C:37]([F:42])[CH:36]=4)[CH:31]=[CH:32][CH:33]=3)=[O:27])=[CH:16][N:15]([S:44]([C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=3)(=[O:45])=[O:46])[C:12]2=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59362379HCID 59362379, compound

Product 1

HCID 68606710HCID 68606710, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a vial was dissolved (1-benzenesulfonyl-3-[3-({[1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carbonyl]-amino}-methyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-ylmethyl}-carbamic acid tert-butyl ester (0.259 mmol) in methylene chloride (2.00 mL, Acros) and trifluoroacetic acid (2.00 mL, 0.0260 mol; Acros). The reaction was stirred for 30 min, then the reaction was evaporated to dryness to give the crude amine.

Workup

  1. customthe reaction was evaporated to dryness

Sources & evidence

ORD record
ord-d0731e5f0a1046a982a906352af8c4cc
Source dataset
uspto-grants-2014_07
Patent number
US08778977B2

Reaction notes

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