Lithium Hydroxide → HCID 58481104, compound

HRID 1625700Notes

Reaction equation

HRID 1625700 reaction equation
[C:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10]([O:12]CC)=[O:11])=[CH:6][C:5]=1[NH2:17])(=[O:3])[CH3:2].[Li+:18].[OH-]>C1COCC1>[C:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10]([O-:12])=[O:11])=[CH:6][C:5]=1[NH2:17])(=[O:3])[CH3:2].[Li+:18]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 58481143HCID 58481143, compound

Product 1

HCID 58481104HCID 58481104, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 2-(4-acetyl-3-aminophenoxy)acetate (TU3205-036) (1.02 g) was dissolved in THF (17 mL) and treated with aqueous LiOH (1 M, 4.3 mL) at ambient temperature for 1 hour. LC-MS analysis showed a clean complete reaction. The reaction mixture was concentrated under reduced pressure, affording lithium 2-(4-acetyl-3-aminophenoxy)acetate (TU3205-042) as a yellowish solid. MS (ESI+): calcd. for free acid 210.10. found 210.10 (MH+).

Workup

  1. customa clean complete reaction
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-14d33556c0a641fb8d6c5d4fcb5818ef
Source dataset
uspto-grants-2014_07
Patent number
US08785151B2

Reaction notes

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