O-Xylene → HCID 67078397, compound

HRID 1625986Notes

Reaction equation

HRID 1625986 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.C[CH2:11][O:12]C(C1C(=O)CCCC1)=O.[C:22]1(C)[C:23](C)=[CH:24][CH:25]=[CH:26][CH:27]=1>>[Br:9][C:5]1[CH:6]=[C:7]2[NH:8][C:11](=[O:12])[N:1]([C:27]3[CH2:26][CH2:25][CH2:24][CH2:23][CH:22]=3)[C:2]2=[N:3][CH:4]=1

Participants

4

Reactant 3

HCID 7237O-XyleneHCID 95543Ethyl 2-oxocyclohexanecarboxylateHCID 6911565-Bromopyridine-2,3-diamine

Product 1

HCID 67078397HCID 67078397, compound

Procedure

2,3-Diamino-5-bromopyridine (50 g) and 2-cyclohexanonecarboxylic acid ethyl ester (63.5 ml) were heated under reflux in xylene (2000 ml) for 64 hours. The reaction solution was cooled to room temperature and the precipitated crystals were collected by filtration. The resulting crude crystals were recrystallized from toluene to give the title compound (30 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe resulting crude crystals were recrystallized from toluene

Sources & evidence

ORD record
ord-ab878942854a464fa73ff5998127cd52
Source dataset
uspto-grants-2014_07
Patent number
US08785438B2

Reaction notes

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