Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 58082769, compound

HRID 1626118Notes

Reaction equation

HRID 1626118 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:10]([F:13])([F:12])[F:11])=[C:5]([C:7]([OH:9])=O)[N:6]=1.Cl.[CH3:15][NH:16][O:17][CH3:18].Cl.CN(C)CCCN=C=NCC>>[CH3:18][O:17][N:16]([CH3:15])[C:7]([C:5]1[N:6]=[C:2]([CH3:1])[O:3][C:4]=1[C:10]([F:13])([F:12])[F:11])=[O:9]

Participants

4

Reactant 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27756512-methyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxylic Acid

Product 1

HCID 58082769HCID 58082769, compoundYield 92%

Procedure

In a manner analogous to that described in Example 1 d), the condensation of 2-methyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N,O-dimethylhydroxylamine hydrochloride by N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride yielded the title compound (92% yield) as a colorless oil. MS (ISP): m/z=239.0 [M+H]+.

Workup

  1. customthat described in Example 1 d

Sources & evidence

ORD record
ord-a433e4436c4e4c29a6a89899412d62e1
Source dataset
uspto-grants-2014_07
Patent number
US08785436B2

Reaction notes

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