Trifluoroacetic acid → HCID 178448937, compound

HRID 1626263Notes

Reaction equation

HRID 1626263 reaction equation
[I-].C([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH3:36])[C:18]3[C:27]([CH:28]=2)=[S+:26][C:25]2[C:20](=[C:21]([CH3:35])[CH:22]=[C:23]([N:29]([CH3:34])[CH2:30][CH2:31][CH2:32][CH3:33])[CH:24]=2)[N:19]=3)[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>ClCCl>[F:37][C:38]([F:43])([F:42])[C:39]([O-:41])=[O:40].[N:12]1([C:15]2[CH:16]=[C:17]([CH3:36])[C:18]3[C:27]([CH:28]=2)=[S+:26][C:25]2[C:20](=[C:21]([CH3:35])[CH:22]=[C:23]([N:29]([CH3:34])[CH2:30][CH2:31][CH2:32][CH3:33])[CH:24]=2)[N:19]=3)[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178448939HCID 178448939, compound

Product 1

HCID 178448937HCID 178448937, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-(4-Boc-piperazin-1-yl)-7-(methyl(n-butyl)amino)-1,9-dimethylphenothiazin-5-ium iodide (25 mg) in dichloromethane (5 mL) and trifluoroacetic acid (2 mL) was stirred for 4 h at room temperature. The resulting mixture was concentrated to dryness, rinsed out by toluene (3×10 mL) and dried under vacuum to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. washrinsed out by toluene (3×10 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-1a98abd29ac642f9b9afd949d66e6f4b
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

Loading…