1-Methylpiperazine → HCID 178436997, compound

HRID 1626265Notes

Reaction equation

HRID 1626265 reaction equation
O.[I-:2].[I-].[I-].[I-].[CH2:6]([C:8]1[C:21]2[C:12](=[S+:13][C:14]3[C:19]([N:20]=2)=[C:18]([CH3:22])[CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)[CH3:7].C(C1[C:38]2[C:29](=[S+][C:31]3[C:36]([N:37]=2)=C(C)C=CC=3)C=CC=1)C.C(C1C2C(=[S+]C3[C:53]([N:54]=2)=C(C)C=CC=3)C=CC=1)C.C(C1C2C(=[S+]C3C(N=2)=C(C)C=CC=3)C=CC=1)C.[CH3:74][N:75]1[CH2:80][CH2:79][NH:78][CH2:77][CH2:76]1>CO>[I-:2].[CH3:74][N:75]1[CH2:80][CH2:79][N:78]([C:10]2[C:9]([N:37]3[CH2:36][CH2:31][N:54]([CH3:53])[CH2:29][CH2:38]3)=[C:8]([CH2:6][CH3:7])[C:21]3[C:12]([CH:11]=2)=[S+:13][C:14]2[C:19](=[C:18]([CH3:22])[CH:17]=[CH:16][CH:15]=2)[N:20]=3)[CH2:77][CH2:76]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 866670301-Ethyl-9-methylphenothiazin-5-ium tetraiodide hydrate

Product 1

HCID 178436997HCID 178436997, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-ethyl-9-methylphenothiazin-5-ium tetraiodide hydrate (50 mg, 0.07 mmol) in methanol (10 mL) and 1-methylpiperazine (30 mg, 0.3 mmol) was stirred for 2 h at room temperature. The resulting mixture was concentrated to dryness and purified by flash chromatography using the methanol-chloroform gradient to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. custompurified by flash chromatography

Sources & evidence

ORD record
ord-c08096aee9514845a0d8d3545066df5a
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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