Methanol → HCID 178436810, compound

HRID 1626267Notes

Reaction equation

HRID 1626267 reaction equation
[I-:1].[I-].[I-].CO[CH2:6][CH2:7][N:8]([CH2:26][CH2:27]OC)[C:9]1[CH:10]=[C:11]([CH3:25])[C:12]2[C:21]([CH:22]=1)=[S+:20][C:19]1[C:14](=[C:15]([CH2:23][CH3:24])[CH:16]=[CH:17][CH:18]=1)[N:13]=2.[CH3:30][O:31][CH2:32][CH2:33][N:34](C1C=C(C)C2C(C=1)=[S+]C1C(=C(CC)C=CC=1)N=2)[CH2:35][CH2:36]OC.COC[CH2:59][N:60](C1C=C(C)C2C(C=1)=[S+]C1C(=C(CC)C=CC=1)N=2)CCOC.CN1CCNCC1.[CH3:89][OH:90]>>[I-:1].[CH3:89][O:90][CH2:36][CH2:35][N:34]([CH2:33][CH2:32][O:31][CH3:30])[C:17]1[CH:16]=[C:15]([CH2:23][CH3:24])[C:14]2[C:19]([CH:18]=1)=[S+:20][C:21]1[C:12](=[C:11]([CH3:25])[CH:10]=[C:9]([N:8]3[CH2:7][CH2:6][N:60]([CH3:59])[CH2:27][CH2:26]3)[CH:22]=1)[N:13]=2

Participants

4

Reactant 3

HCID 887MethanolHCID 531671-MethylpiperazineHCID 178435889HCID 178435889, compound

Product 1

HCID 178436810HCID 178436810, compound

Procedure

A solution of 3-(bis(2-methoxyethyl)amino)-9-ethyl-1-methylphenothiazin-5-ium triiodide (150 mg, 0.2 mmol) in methanol (10 mL) and 1-methylpiperazine (30 mg, 0.3 mmol) was stirred for 2 h at room temperature. The resulting mixture was concentrated to dryness and purified by flash chromatography using the methanol-chloroform gradient to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. custompurified by flash chromatography

Sources & evidence

ORD record
ord-c2f591c3366c44c9afe81847fe60da07
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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