HCID 178436738, compound → HCID 178436734, compound

HRID 1626271Notes

Reaction equation

HRID 1626271 reaction equation
[I-:1].C([N:9]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]2[CH:17]=[C:18]([CH2:45][CH3:46])[C:19]3[C:28]([CH:29]=2)=[S+:27][C:26]2[C:21](=[C:22]([CH3:44])[CH:23]=[C:24]([N:30]4[CH2:36][CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]4)[CH:25]=2)[N:20]=3)[CH2:11][CH2:10]1)(OC(C)(C)C)=O>ClCCl.FC(F)(F)C(O)=O>[I-:1].[N:12]1([C:16]2[CH:17]=[C:18]([CH2:45][CH3:46])[C:19]3[C:28]([CH:29]=2)=[S+:27][C:26]2[C:21](=[C:22]([CH3:44])[CH:23]=[C:24]([N:30]4[CH2:36][CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=2)[N:20]=3)[CH2:13][CH2:14][CH2:15][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 1

HCID 178436738HCID 178436738, compound

Product 1

HCID 178436734HCID 178436734, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

a solution of 3,7-bis(4-Boc-1,4-diazepan-1-yl)-1-ethyl-9-methyl-phenothiazin-5-ium iodide (75 mg, 0.01 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (1.0 mL) was stirred for 3 h at 50° C. The resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL) and concentrated to dryness.

Workup

  1. washThe resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL)
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-bc5c998a4f8f4fc884d3525149b7b85e
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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