反应详情

(S)-4-(2-chloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine hydrochloride (intermediate 6) (163 mg, 0.56 mmol) was stirred in THF (2 mL) with pivaldehyde (0.124 mL, 1.12 mmol) and triethylamine (0.234 mL, 1.68 mmol). After 1 h sodium triacetoxyborohydride (237 mg, 1.12 mmol) was added and the reaction was stirred overnight. Water and ethyl acetate were added. The organic layer was washed (brine) and concentrated in vacuo to give an orange oil, which was used crude.

1. washThe organic layer was washed (brine)
2. concentrationconcentrated in vacuo
3. customto give an orange oil, which