反应详情

温度

20 °C

To a stirring solution of (S)-4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)aniline (intermediate 9) (311 mg, 0.96 mmol) and NaHCO3 (120 mg, 1.43 mmol) in dry THF, was added phenyl chloroformate (133 μL, 1.05 mmol) dropwise. The reaction mixture was stirred at room temperature (20° C.) for 2 hours, before partitioning the crude reaction mixture between water and EtOAc. The phases were separated and the organic layer dried over magnesium sulphate, filtered and then reduced in vacuo, affording the title compound as a pink solid (425 mg, 100%).

1. custombefore partitioning the crude
2. customreaction mixture between water and EtOAc
3. customThe phases were separated
4. dry with materialthe organic layer dried over magnesium sulphate
5. filtrationfiltered