Hydrochloric Acid → HCID 66680278, compound

HRID 1626748Notes

Reaction equation

HRID 1626748 reaction equation
C(O)C.[OH-].[Na+].[O:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11]1[CH:12]=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([O:18]CC)=[O:17].Cl>O>[O:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11]1[CH:12]=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 86661493HCID 86661493, compound

Product 1

HCID 66680278HCID 66680278, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 mL of ethanol and 4.0 mL of 1N aqueous sodium hydroxide solution were added to 615 mg (2.50 mmol) of ethyl [3-(furan-2-yl)phenoxy]acetate, and the mixture was stirred at room temperature for 4 hours. 1N hydrochloric acid was added to acidify the reaction mixture, and water was added thereto. The precipitated solids were collected by filtration, washed with water, and air-dried, thereby giving 448 mg of [3-(furan-2-yl)phenoxy]acetic acid (yield: 82%).

Workup

  1. additionwas added
  2. filtrationThe precipitated solids were collected by filtration
  3. washwashed with water
  4. customair-dried

Sources & evidence

ORD record
ord-59ffac7b100e4c908a6f92f068c544a9
Source dataset
uspto-grants-2014_07
Patent number
US08785473B2

Reaction notes

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