反应详情

5 mL of THF was added to 400 mg (1.76 mmol) of 4-(adamantan-1-yl)aniline, after which 292 mg (2.11 mmol) of potassium carbonate was added. 291 mg (1.94 mmol) of ethyl chloroglyoxylate was added at 0° C., and the mixture was stirred at room temperature for 2 hours. Thereafter, the mixture was filtered using silica gel, and the filtrate was condensed. The obtained crude product was then separated and purified by silica gel column chromatography, thereby quantitatively giving ethyl {[4-(adamantan-1-yl)phenyl]amino}(oxo)acetate.

1. filtrationThereafter, the mixture was filtered
2. customcondensed
3. customThe obtained crude product
4. customwas then separated
5. custompurified by silica gel column chromatography