反应详情

温度

70 °C

THF (18 mL) and ethanol (6 mL) were added to 600 mg (1.83 mmol) of ethyl {[4-(adamantan-1-yl)phenyl]amino}(oxo)acetate. Thereafter, 2.7 mL of 1N aqueous sodium hydroxide solution was added, and the mixture was heated at 70° C. for 2 hours. Next, 1N hydrochloric acid was added to acidify the mixture, and the organic solvent was distilled off under reduced pressure. The resulting solids were filtered and washed with H2O and n-hexane, followed by drying, thereby giving 492 mg of {[4-(adamantan-1-yl)phenyl]amino}(oxo)acetic acid (yield: 90%).

1. distillationthe organic solvent was distilled off under reduced pressure
2. filtrationThe resulting solids were filtered
3. washwashed with H2O and n-hexane
4. customby drying