反应详情

温度

0 °C

Ethyl 2-(4-(methoxymethoxy)phenyl)propanoate (485 mg, 2.04 mmol) in methylene chloride (10 mL) was added trifluoroacetic acid (5 mL) at 0° C. The mixture was stirred for 40 minutes at 0° C. and then slowly added solid sodium bicarbonate (7.14 g) and water (100 mL) at 0° C. The mixture was extracted with methylene chloride. The organic layer was dried with MgSO4. The organic layer was filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=4/1.

1. customat 0° C
2. extractionThe mixture was extracted with methylene chloride
3. dry with materialThe organic layer was dried with MgSO4
4. filtrationThe organic layer was filtered
5. concentrationthe filtrate was concentrated in vacuo
6. customThe residue was purified by column chromatography
7. washeluting with n-Hexane/EtOAc=4/1