反应详情

4-Bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-ol (Example 1-2) (704 mg, 2.478 mmol, 1.0 equiv.), 3-bromomethylphenylboronic acid (11) (639 mg, 2.97 mmol, 1.2 equiv.) and cesium carbonate (969 mg, 2.97 mmol, 1.2 equiv.) were suspended in anhydrous DMF (6043 μl). The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with Et2O, and acidified with aqueous saturated NH4Cl and HCl (1N) to pH 2. The organic layer was dried over MgSO4, filtered and concentrated to provide the titled compound. LRMS m/z (M+H) 418.0 and 420.0 (intensity ratio ˜1:1) found, 418.1 and 420.1 required.

1. dry with materialThe organic layer was dried over MgSO4
2. filtrationfiltered
3. concentrationconcentrated