Triethylamine → HCID 58293466, compound

HRID 1627103Notes

Reaction equation

HRID 1627103 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:13][CH3:14])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN(C(ON1N=NC2[CH:26]=[CH:27][CH:28]=[N:29][C:24]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.N1CCCC1.CCN(CC)CC>C(Cl)Cl>[O:12]=[C:10]([N:29]1[CH2:28][CH2:27][CH2:26][CH2:24]1)[C@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:13][CH3:14]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 2755936(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Product 1

HCID 58293466HCID 58293466, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of (R)-2-(tert-butoxycarbonylamino)butanoic acid (1.5 g, 7.38 mmol), HATU (3.37 g, 8.86 mmol) and pyrrolidine (1.303 mL, 14.76 mmol) in DCM (50 mL) was added Et3N (2.057 mL, 14.76 mmol). The reaction mixture was stirred at room temperature for 5 h and then washed with saturated aqueous NaHCO3 and brine. The organics were dried over MgSO4 and concentrated. Purification by silica column chromatography (MeOH/DCM, 0-10%) afforded the title compound as a light yellow oil (1.6 g, 85%). 1H NMR (500 MHz, CDCl3) δ 0.88-1.04 (m, 3 H) 1.38-1.48 (m, 9 H) 1.52-1.64 (m, 1 H) 1.69-1.79 (m, 1 H) 1.82-1.92 (m, 2 H) 1.92-2.02 (m, 2 H) 3.36-3.47 (m, 2 H) 3.53 (dt, J=12.08, 7.14 Hz, 1 H) 3.65 (dt, J=10.01, 6.47 Hz, 1 H) 4.30-4.43 (m, 1 H) 5.37 (d, J=8.30 Hz, 1 H).

Workup

  1. washwashed with saturated aqueous NaHCO3 and brine
  2. dry with materialThe organics were dried over MgSO4
  3. concentrationconcentrated
  4. customPurification by silica column chromatography (MeOH/DCM, 0-10%)

Sources & evidence

ORD record
ord-ae9b2e50fa624cbc86b964e2176f0e42
Source dataset
uspto-grants-2014_07
Patent number
US08785429B2

Reaction notes

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