Hydrochloric Acid → HCID 178489935, compound

HRID 1627394Notes

Reaction equation

HRID 1627394 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([NH:14][NH:15][C:16](=[S:25])[NH:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[CH2:11][C:12]1[N:17]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:16]([SH:25])=[N:15][N:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2732212HCID 2732212, compound

Product 1

HCID 178489935HCID 178489935, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 2-(2-(3,4-dimethoxyphenyl)acetyl)-N-(4-fluorophenyl)hydrazine-carbothioamide (2.03 g) in 2N NaOH (200 mL) was heated at reflux 3 h. The reaction was cooled and acidified to pH 5 with 2N HCl. White solids precipitated, were collected by filtration and washed with water. The solids were dried under vacuum to yield the title compound (1.56 g, 81%).

Workup

  1. temperatureat reflux 3 h
  2. temperatureThe reaction was cooled
  3. customWhite solids precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customThe solids were dried under vacuum

Sources & evidence

ORD record
ord-dbc706831e13444d938a7494f24d449b
Source dataset
uspto-grants-2014_07
Patent number
US08785488B2

Reaction notes

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