反应详情

温度

85 °C

2 M HCl (0.2 mL) is added to solution of compound A1 (0.97 mmol) in 2 mL of ethanol. The mixture is then put in an ice bath and Fe powder (365 mg) is added slowly. The reaction is heated to 85° C. for 1 hr and cooled to room temperature. Celite (0.5 g) is added to stir and the resulting mixture is filtered through a bed of celite and rinsed with ethanol. The filtrated is evaporated to give a brown oil residue, compound A2. The residue is used without further purification.

1. customThe mixture is then put in an ice bath
2. temperaturecooled to room temperature
3. additionCelite (0.5 g) is added
4. filtrationthe resulting mixture is filtered through a bed of celite and
5. washrinsed with ethanol
6. customThe filtrated is evaporated