反应详情

To a solution of 4-(4-bromo-pyrazol-1-yl)-piperidine (375 mg, 1.63 mmol) in DMF (3.26 mL) was added NEt3 (230 μL, 1.63 mmol) and stirred for 5 minutes. Methyliodide (MeI) (1.63 mL, 1M MeI in DMF, freshly made) was added and the reaction was stirred overnight at room temperature. Water was added and the solution was extracted with EtOAc (4×10 mL). The organic solution was washed with brine, dried with Na2SO4, concentrated, and dried in vacuo to afford 4-(4-bromo-pyrazol-1-yl)-1-methyl-piperidine (251 mg, 63% yield).

1. additionwas added
2. stirringthe reaction was stirred overnight at room temperature
3. extractionthe solution was extracted with EtOAc (4×10 mL)
4. washThe organic solution was washed with brine
5. dry with materialdried with Na2SO4
6. concentrationconcentrated
7. customdried in vacuo