Hydroxylamine → HCID 11588872, compound

HRID 1627753Notes

Reaction equation

HRID 1627753 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]([S:13]([N:16]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23](Cl)=[O:24])=[CH:17]2)(=[O:15])=[O:14])=[CH:10][CH:9]=1.[NH2:26][OH:27]>O>[OH:27][NH:26][C:23](=[O:24])/[CH:22]=[CH:21]/[C:18]1[CH:19]=[CH:20][N:16]([S:13]([C:11]2[S:12][C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=3)=[CH:9][CH:10]=2)(=[O:15])=[O:14])[CH:17]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 86653103HCID 86653103, compound

Product 1

HCID 11588872HCID 11588872, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

The above prepared solution of (E)-3-[1-(5-Pyridin-2-yl-thiophene-2-sulfonyl)-1H-pyrrol-3-yl]-acryloyl chloride hydrochloride was added to an aqueous hydroxylamine solution (50%, 150 g, 2.27 mop at 20-25° C. over a period of 45 min. After stirring for 65 min, water (300 mL) was added and cooled to 0° C. The suspension was filtered and the filter cake was washed with water (150 mL). The title compound was obtained as beige solid (17.3 g).

Workup

  1. filtrationThe suspension was filtered
  2. washthe filter cake was washed with water (150 mL)

Sources & evidence

ORD record
ord-15f1844a86b04fda87f7e2d6615f21e7
Source dataset
uspto-grants-2014_07
Patent number
US08785659B2

Reaction notes

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