反应详情

温度

95 °C

7-bromo-2.3-dihydropyrano[4.3.2-de]quinoline (0.170 g; 0.680 mmol), bis(pinacolato)diboron (0.207 g; 0.816 mmol), anhydrous potassium acetate (0.133 g; 1.36 mmol) and bis(tricyclohexylphosphine)palladium(0) (0.045 g; 0.068 mmol) in anhydrous 1.4-dioxane (3.1 mL) were mixed in a tube, purged with argon and sealed. After heating at 95° C. for 16 h, the mixture was cooled at room temperature, concentrated under reduced pressure and store at 3° C. for 21 h. The brown residue was dissolved in acetonitrile, filtered, and the dark brown solution was concentrated under reduced pressure. Purification by preparative HPLC (HPLC method 1) furnished 0.044 g (25%) of the title compound as an amorphous solid.

1. custompurged with argon
2. customsealed
3. temperaturethe mixture was cooled at room temperature
4. concentrationconcentrated under reduced pressure and store at 3° C. for 21 h
5. dissolutionThe brown residue was dissolved in acetonitrile
6. filtrationfiltered
7. concentrationthe dark brown solution was concentrated under reduced pressure
8. customPurification by preparative HPLC (HPLC method 1)