3-Aminopyridine → HCID 67215728, compound

HRID 1627951Notes

Reaction equation

HRID 1627951 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH3:8])[CH:5]=[CH:6][CH:7]=1.[NH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1>>[C:4]1([CH3:8])[CH:5]=[CH:6][CH:7]=[C:2]([N:12]2[CH:13]=[CH:14][CH:15]=[C:10]([NH2:9])[CH2:11]2)[CH:3]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 115603-Bromotoluene

Product 1

HCID 67215728HCID 67215728, compoundYield 98%

Procedure

Following the general procedure using 3-bromotoluene (121 μL, 1.00 mmol) and 3-aminopyridine (113 mg, 1.20 mmol), the reaction was stirred for 20 h at rt. Column chromatography on silica gel (eluting with 40% EtOAc/hexanes) afforded the product as an off-white solid (180 mg, 98%).

Sources & evidence

ORD record
ord-44cdc59b1ae247c1896f6b9cc883cb45
Source dataset
uspto-grants-2014_07
Patent number
US08785665B2

Reaction notes

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