Potassium Carbonate → HCID 67496215, compound

HRID 1628250Notes

Reaction equation

HRID 1628250 reaction equation
C([O:4][C@H:5]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:6]([NH:8][C:9]1[N:13]([CH2:14][CH3:15])[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:10]=1)=[O:7])(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH2:14]([N:13]1[C:9]([NH:8][C:6](=[O:7])[C@H:5]([OH:4])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:10][C:11]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[N:12]1)[CH3:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 67497428HCID 67497428, compound

Product 1

HCID 67496215HCID 67496215, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To (R)-1-(1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-yl acetate (438 mg, 1157 μmol) was added K2CO3 (320 mg, 2315 μmol), followed by MeOH. After 1 hr, the reaction was completed by LC/MS. The reaction was concentrated and worked up with brine and 30% isopropanol in CHCl3. The crude material was purified by trituration with dichloromethane followed by filtration.

Workup

  1. concentrationThe reaction was concentrated
  2. customThe crude material was purified by trituration with dichloromethane
  3. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-f9645a33045643949bf2d5422fbf6032
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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