Methanol → 9-Chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylic acid

HRID 1629271Notes

Reaction equation

C[O:2][C:3]([C:5]1[N:14]=[C:13]2[N:7]([CH2:8][CH2:9][O:10][C:11]3[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:12]=32)[N:6]=1)=[O:4].CO.O.[Li+].[OH-]>C1COCC1>[Cl:19][C:17]1[CH:16]=[CH:15][C:12]2[C:13]3[N:7]([N:6]=[C:5]([C:3]([OH:4])=[O:2])[N:14]=3)[CH2:8][CH2:9][O:10][C:11]=2[CH:18]=1

Participants

Conditions

Temperature: 25 °C

Procedure

Methyl-9-chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylate (0.144 g, 0.515 mmol) was dissolved in 3:2:1 THF:MeOH:H2O (5.0 mL), and treated with 4 N aqueous LiOH (0.644 mL). The mixture was stirred for 30 min at 25° C. The reaction was quenched with 1 N aq. HCl (10 mL) and the solution was extracted with EtOAc (3×20 mL). The combined organic extracts were dried with Na2SO4 and concentrated in vacuo to give 9-Chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylic acid (89% yield)

Workup

customThe reaction was quenched with 1 N aq. HCl (10 mL)
extractionthe solution was extracted with EtOAc (3×20 mL)
dry with materialThe combined organic extracts were dried with Na2SO4
concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-1e7955d2111f4a4faf17f4295fe98736
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785626B2

Reaction notes

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