Tetrahydrofuran → 4-(1-((2-(Imidazo[1,2-a]pyridin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)morpholine

HRID 162954Notes

Reaction equation

HRID 162954 reaction equation
[Br:42][c:43]1[cH:44][cH:45][cH:46][c:47]2[n:48]1[cH:49][cH:50][n:51]2.[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[Cu:57][I:58].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11]([Sn:13]([CH2:14][CH2:15][CH2:16][CH3:17])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH2:24][CH3:25])[n:12]2)[cH:26][c:27]([CH2:29][N:30]2[CH2:31][CH2:32][CH:33]([N:36]4[CH2:37][CH2:38][O:39][CH2:40][CH2:41]4)[CH2:34][CH2:35]2)[s:28]3)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11](-[c:43]4[cH:44][cH:45][cH:46][c:47]5[n:48]4[cH:49][cH:50][n:51]5)[n:12]2)[cH:26][c:27]([CH2:29][N:30]2[CH2:31][CH2:32][CH:33]([N:36]4[CH2:37][CH2:38][O:39][CH2:40][CH2:41]4)[CH2:34][CH2:35]2)[s:28]3)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 130372415-Bromoimidazo(1,2-a)pyridineHCID 596059194-Morpholin-4-yl-6-(4-morpholin-4-ylpiperidin-1-ylmethyl)-2-(tributylstannanyl)thieno[3,2-d]pyrimidine

Product 1

HCID 498331094-(1-((2-(Imidazo[1,2-a]pyridin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)morpholine

Sources & evidence

ORD record
ord-546506f0bbae4c43b4b71c1e6fcc6479
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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