Azide → HCID 57517329, compound

HRID 1629716Notes

Reaction equation

HRID 1629716 reaction equation
[N-]=[N+]=[N-].[N:4]([C:7]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([CH3:17])[CH:11]=1)([CH3:9])[CH3:8])=[N+]=[N-]>CO.O.[Pt](=O)=O>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:7]([NH2:4])([CH3:8])[CH3:9])=[CH:11][C:12]=1[CH3:17]

Participants

5

Reactant 2

HCID 33558AzideHCID 575173284-(1-Azido-1-methylethyl)-1-chloro-2-methylbenzene

Product 1

HCID 57517329HCID 57517329, compound

Reagents, catalysts & solvents 2

HCID 11139377Platinum dioxide monohydrateCatalystHCID 887MethanolSolvent

Procedure

A solution of azide INT 21 (4.58 g, 21.84 mmol) in MeOH (100 mL) was hydrogenated at room temperature under atmospheric pressure for 6 hours in the presence of platinum dioxide hydrate (268 mg, 1.1 mmol). The mixture was filtered through Celite and concentrated. The crude was used without further purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated
  3. customThe crude was used without further purification

Sources & evidence

ORD record
ord-50ccf86980934dd5ace9df5ff3dd3c1c
Source dataset
uspto-grants-2014_07
Patent number
US08791100B2

Reaction notes

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