tert-Butyl acrylate → HCID 57517341, 화합물

HRID 1629755노트

반응식

HRID 1629755 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C@@H:8]([NH2:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[C:11]([O:15][C:16](=[O:19])[CH:17]=[CH2:18])([CH3:14])([CH3:13])[CH3:12]>C(O)C>[C:11]([O:15][C:16](=[O:19])[CH2:17][CH2:18][NH:10][C@H:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:9])([CH3:14])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 15458tert-Butyl acrylateHCID 9952938(S)-1-(3-bromophenyl)ethanamine

생성물 1

HCID 57517341HCID 57517341, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of (S)-1-(3-bromo-phenyl)-ethylamine (0.3 g, 1.5 mmol) and acrylic acid tert-butyl ester (0.19 g, 1.50 mmol) in ethanol (1.3 mL) was stirred at 55° C. for 2.5 hours. The solvent was concentrated and the crude residue was purified by chromatography on silica gel (heptane/EtOAc).

후처리

  1. concentrationThe solvent was concentrated
  2. customthe crude residue was purified by chromatography on silica gel (heptane/EtOAc)

출처 및 근거

ORD 기록
ord-06a8046b84264402913513ce68c0a9b8
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791100B2

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