Diisopropylethylamine → HCID 178431712, compound

HRID 1629889Notes

Reaction equation

HRID 1629889 reaction equation
[Cl:1][C:2]1[C:3]([N:11]2[CH:15]([CH3:16])[CH2:14][O:13][C:12]2=[O:17])=[C:4]([CH:8]=[CH:9][CH:10]=1)C(O)=O.[Cl:18][C:19]1[CH:30]=[CH:29][C:22]2[NH:23][C:24]([C@@H:26]([NH2:28])[CH3:27])=[N:25][C:21]=2[CH:20]=1.CN([C:34]([O:38]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>C1COCC1>[Cl:1][C:2]1[CH:10]=[C:9]([CH:8]=[CH:4][C:3]=1[N:11]1[CH:15]([CH3:16])[CH2:14][O:13][C:12]1=[O:17])[C:34]([NH:28][C@H:26]([C:24]1[NH:23][C:22]2[CH:29]=[CH:30][C:19]([Cl:18])=[CH:20][C:21]=2[N:25]=1)[CH3:27])=[O:38]

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 42034613(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 67048210HCID 67048210, compound

Product 1

HCID 178431712HCID 178431712, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 1f from 3-chloro-(4-methyl-2-oxo-oxazolidin-3-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine, TBTU and DIPEA in THF and purification of the residue by chromatography on aluminium oxide.

Sources & evidence

ORD record
ord-f3f8ada73b854fe9a3832e0eb6828b85
Source dataset
uspto-grants-2014_07
Patent number
US08791103B2

Reaction notes

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