Sodium hydride → HCID 86681767, compound

HRID 1629935Notes

Reaction equation

HRID 1629935 reaction equation
[CH3:1][N:2]1[CH2:5][CH:4]([OH:6])[CH2:3]1.[Cl:7][C:8]1[CH:13]=[N:12][CH:11]=[C:10](Cl)[N:9]=1.[H-].[Na+]>CN(C=O)C>[Cl:7][C:8]1[CH:13]=[N:12][CH:11]=[C:10]([O:6][CH:4]2[CH2:5][N:2]([CH3:1])[CH2:3]2)[N:9]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 785042,6-DichloropyrazineHCID 138139271-Methylazetidin-3-ol

Product 1

HCID 86681767HCID 86681767, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-chloro-6-((1-methylazetidin-3-yl)oxy)pyrazine (129) was prepared by reacting 1-methylazetidin-3-ol (50 mg, 0.336 mmol, 1 eq) and 2,6-dichloropyrazine (32) (29.2 mg, 0.336 mmol, 1 eq) in DMF (5 mL) and sodium hydride (16.11 mg, 0.671 mmol, 2 eq) under refluxing temperature for 8 hrs.

Workup

  1. temperatureunder refluxing temperature for 8 hrs

Sources & evidence

ORD record
ord-b143d49d73dd44a0a8e82996b5d3d19b
Source dataset
uspto-grants-2014_07
Patent number
US08791112B2

Reaction notes

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