Tetrahydrofuran → 3-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione
Reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:33][Si:34]([CH3:35])([CH3:36])[N-:37][Si:38]([CH3:39])([CH3:40])[CH3:41].[Cl:1][c:2]1[c:3]([F:23])[c:4](=[O:22])[n:5]([CH3:21])[c:6]2[n:7][cH:8][n:9]([CH2:13][CH:14]3[O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]3)[c:10](=[O:12])[c:11]12.[F:24][c:25]1[c:26]([NH2:27])[cH:28][cH:29][c:30]([I:32])[cH:31]1.[Li+:42]>>[c:2]1([NH:27][c:26]2[c:25]([F:24])[cH:31][c:30]([I:32])[cH:29][cH:28]2)[c:3]([F:23])[c:4](=[O:22])[n:5]([CH3:21])[c:6]2[n:7][cH:8][n:9]([CH2:13][CH:14]3[O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]3)[c:10](=[O:12])[c:11]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-608eb460267349f3917c99c9c29d5157
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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