3,4,5-Trimethoxyaniline → HCID 59343421, compound

HRID 16306Notes

Reaction equation

HRID 16306 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:17]=2[C:16](=[O:18])[CH2:15][CH2:14]3)[N:3]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[NH2:24]>CCOC(C)=O>[CH3:31][O:30][C:26]1[CH:25]=[C:23]([NH:24][C:2]2[CH:7]=[N:6][CH:5]=[C:4]([O:8][C:9]3[CH:10]=[CH:11][CH:12]=[C:13]4[C:17]=3[C:16](=[O:18])[CH2:15][CH2:14]4)[N:3]=2)[CH:22]=[C:21]([O:20][CH3:19])[C:27]=1[O:28][CH3:29]

Participants

4

Reactant 2

HCID 322853,4,5-TrimethoxyanilineHCID 59343426HCID 59343426, compound

Product 1

HCID 59343421HCID 59343421, compoundYield 4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using Method EE with 2-chloro-6-(indanone-7-oxy)-pyrazine (200 mg, 0.77 mmol) and 169 mg (0.92 mmol) 3,4,5-trimethoxyaniline (169 mg, 0.92 mmol), and purification by column chromatography (AcOEt), the title compound was obtained (11 mg). Yield: 4%.

Sources & evidence

ORD record
ord-44b38a5132d74c94b773f90e0abb3709
Source dataset
uspto-grants-2010_06
Patent number
US07737152B2

Reaction notes

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