Sodium Sulfide → HCID 178494292, compound

HRID 1630718Notes

Reaction equation

HRID 1630718 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C@@H:18]([OH:21])[CH2:19][OH:20])=[CH:12][CH:11]=2)[C:5]([C:22]#[N:23])=[C:4]([O:24][CH3:25])[N:3]=1.[S-2:26].[Na+].[Na+]>CN(C=O)C>[OH:21][C@@H:18]([CH2:19][OH:20])[CH2:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([C:6]2[C:7]([C:8]#[N:9])=[C:2]([SH:26])[N:3]=[C:4]([O:24][CH3:25])[C:5]=2[C:22]#[N:23])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14804Sodium SulfideHCID 87241567HCID 87241567, compound

Product 1

HCID 178494292HCID 178494292, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

100 mg (0.278 mmol) of 2-chloro-4-(4-{[(2S)-2,3-dihydroxypropyl]oxy}phenyl)-6-methoxypyridine-3,5-dicarbonitrile are initially charged in 5 ml of DMF, 26 mg (0.334 mmol) of sodium sulphide are added and the mixture is stirred at room temperature for 4 hours. The reaction mixture is reacted further without any further purification.

Workup

  1. customThe reaction mixture is reacted further without any further purification

Sources & evidence

ORD record
ord-644af2dda9f14887a2914e59da1fb206
Source dataset
uspto-grants-2014_07
Patent number
US08791146B2

Reaction notes

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