Trifluoroacetic acid → HCID 178452429, compound

HRID 1631446Notes

Reaction equation

HRID 1631446 reaction equation
[N:1]1([C:7]([O:9][CH2:10][C:11]([CH3:39])([CH3:38])[C:12]([N:14]([C@H:24]2[CH2:29][CH2:28][C@H:27]([NH:30]C(OC(C)(C)C)=O)[CH2:26][CH2:25]2)CC2C=CC(OC)=CC=2)=[O:13])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>ClCCl>[N:1]1([C:7]([O:9][CH2:10][C:11]([CH3:39])([CH3:38])[C:12]([NH:14][C@H:24]2[CH2:25][CH2:26][C@H:27]([NH2:30])[CH2:28][CH2:29]2)=[O:13])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178491195HCID 178491195, compound

Product 1

HCID 178452429HCID 178452429, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 15C (30 mg, 0.055 mmol) in dichloromethane (0.5 mL) was treated with TFA (0.5 mL), and stirred at room temperature for 1.5 h. The reaction mixture was concentrated, and the residue was triturated with Et2O. The resulting off white solid was collected by filtration and air dried to provide 15D. This material was used without purification in the next step.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was triturated with Et2O
  3. filtrationThe resulting off white solid was collected by filtration and air
  4. customdried

Sources & evidence

ORD record
ord-673498031b9c4b258ebe74f10517d788
Source dataset
uspto-grants-2014_07
Patent number
US08791257B2

Reaction notes

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