反应详情

The title compound was prepared in a manner similar to PREPARATION x35 using 4-(5-bromo-2-chloropyrimidin-4-yl)-N-(6-chloro-2,3-dihydro-1H-inden-1-yl)morpholine-3-carboxamide (PREPARATION x40, 567 mg, 1.201 mmol), Xantphos (52.1 mg, 0.090 mmol), palladium(II)acetate (13.48 mg, 0.060 mmol) and potassium phosphate (255 mg, 1.201 mmol) in dioxane (5 mL) and tert-butanol (1 mL). 1H NMR (400 MHz, DMSO-d6) δ 2.21-2.48 (m, 3H), 2.87-3.05 (m, 2H), 3.05-3.21 (m, 1H), 3.47-3.65 (m, 2H), 3.88-4.01 (m, 1H), 4.08-4.32 (m, 2H), 4.39-4.56 (m, 1H), 7.16-7.42 (m, 4H). ESI-MS m/z [M+H]+ calc'd for C18H16Cl2N4O2, 391.07. found 391.3.