反应详情

8-Benzyloxy-1,4-dioxa-spiro[4.5]decane (15 g, 60 mmol) was dissolved in THF (150 ml) and 1M aqueous hydrochloric acid (40 ml) is added and the reaction mixture is heated to reflux overnight. The reaction mixture is cooled and diluted with water (200 ml) before being extracted with ethyl acetate (1×200 ml). The organic extract is washed with saturated solution of sodium bicarbonate and then dried over magnesium sulphate, filtered and evaporated under reduced pressure to give an oil. The oil is distilled under vacuum in a kugelrohr to give 4-benzyloxy-cyclohexanone (10 g).

1. temperaturethe reaction mixture is heated
2. temperatureto reflux overnight
3. temperatureThe reaction mixture is cooled
4. extractionbefore being extracted with ethyl acetate (1×200 ml)
5. extractionThe organic extract
6. washis washed with saturated solution of sodium bicarbonate
7. dry with materialdried over magnesium sulphate
8. filtrationfiltered
9. customevaporated under reduced pressure
10. customto give an oil
11. distillationThe oil is distilled under vacuum in a kugelrohr