Triethylamine → HCID 66707400, compound

HRID 1631920Notes

Reaction equation

HRID 1631920 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15]O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(N(CC)CC)C.CS([Cl:32])(=O)=O>ClCCl>[Cl:32][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][O:7][C:6]2[CH:17]=[CH:18][C:3]([C:2]([F:20])([F:19])[F:1])=[CH:4][CH:5]=2)=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66707473HCID 66707473, compound2×

Product 1

HCID 66707400HCID 66707400, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [4-(4-trifluoromethyl-phenoxymethyl)-phenyl]-methanol (intermediate 14.1.2, 0.34 g, 1.2 mmol) in dichloromethane (10 mL) were added triethylamine (0.34 mL, 2.4 mmol) and methanesulfonyl chloride (0.19 mL, 2.4 mmol). The reaction mixture was stirred at room temperature for 36 h under nitrogen atmosphere. The reaction mixture was washed with water, the organic layer was dried over MgSO4 and the solvent was evaporated under reduced pressure.

Workup

  1. washThe reaction mixture was washed with water
  2. dry with materialthe organic layer was dried over MgSO4
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-27131a47e6564de9af338c6d45e3d920
Source dataset
uspto-grants-2014_07
Patent number
US08791272B2

Reaction notes

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