Acetic Anhydride → 4-Methoxyphenyl acetate

HRID 1632052Notes

Reaction equation

HRID 1632052 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.C([O-])([O-])=O.[K+].[K+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 90154-MethoxyphenolHCID 11430Potassium Carbonate

Product 1

HCID 709874-Methoxyphenyl acetateYield 103.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 4-methoxyphenol (6.2 g, 50 mmol), K2CO3 (10 g, 72 mmol) and acetic anhydride (6.12 g, 60 mmol) in acetone (150 ml) was stirred at RT. over night. The solid was filtered off and washed with acetone (50 ml). After removal of acetone, 8.6 g of product was obtained. Yield: 100%.

Workup

  1. waitover night
  2. filtrationThe solid was filtered off
  3. washwashed with acetone (50 ml)
  4. customAfter removal of acetone

Sources & evidence

ORD record
ord-407483a6e3744d34895315954d60d086
Source dataset
uspto-grants-2014_07
Patent number
US08791267B2

Reaction notes

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