反应详情

Synthesis of ((S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(6-methoxy-3′-nitro-biphenyl-3-ylmethyl)-pyrrolidin-2-one (I-213). Into a 250 mL round-bottomed flask with a stir bar was added I-212 (2.57 g, 11.95 mmol), THF (150 mL), and the solution was cooled to 0° C. NaH (0.56 g, 14.12 mmol) was added and the suspension was stirred at room temperature for 30 minutes. To this, I-70 (3.50 g, 10.86 mmol) was added and the reaction was stirred for 20 hours at room temperature after which time 50 mL of water was added and the product was extracted with ethyl acetate. The organics were concentrated to yield 8.9 g of I-213, which was used as is in the next reaction.

1. additionInto a 250 mL round-bottomed flask with a stir bar was added
2. additionTo this, I-70 (3.50 g, 10.86 mmol) was added
3. additionwas added
4. extractionthe product was extracted with ethyl acetate
5. concentrationThe organics were concentrated
6. customto yield 8.9 g of I-213, which
7. customas is in the next reaction