Hydrochloric Acid → HCID 20444147, compound

HRID 1632245Notes

Reaction equation

HRID 1632245 reaction equation
[OH:1][CH:2](S(O)(=O)=O)[C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.[Na].Cl>>[OH2:1].[CH3:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][O:10][C:7]2[CH:8]=[CH:9][C:4]([C:3](=[O:19])[CH:2]=[O:1])=[CH:5][CH:6]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5360545SodiumHCID 13340089HCID 13340089, compound

Product 1

HCID 20444147HCID 20444147, compound

Procedure

A 2.8 g. portion of α-hydroxy-β-oxo-4-[(4-methylphenyl)methoxy]-benzeneethanesulfonic acid, sodium salt was combined with 25 ml. of 0.5N hydrochloric acid, heated on a steam bath for 5 minutes and then allowed to stand for several hours. The solid was collected, slurried with 50 ml. of acetone, 25 ml. of 0.5N hydrochloric acid were added and the mixture was refluxed for 2 hours. The solid was collected, again refluxed with acid and the solid collected, washed free of acid and dried, giving the desired product as a white solid, m.p. 125°-130° C.

Workup

  1. waitto stand for several hours
  2. customThe solid was collected
  3. additionof 0.5N hydrochloric acid were added
  4. temperaturethe mixture was refluxed for 2 hours
  5. customThe solid was collected
  6. temperatureagain refluxed with acid
  7. customthe solid collected
  8. washwashed free of acid
  9. customdried

Sources & evidence

ORD record
ord-26a973a373974a8aa90aed4239e3ce8c
Source dataset
uspto-grants-1984_10
Patent number
US04474809

Reaction notes

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