Acetic Acid → H-Leu-Leu-Ala-Gln-OH

HRID 1632387Notes

Reaction equation

HRID 1632387 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:20]([NH:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][C:26](=[O:28])[NH2:27])=[O:21])[CH3:19])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(O)(=O)C.Br>CCOCC>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:20]([NH:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][C:26](=[O:28])[NH2:27])=[O:21])[CH3:19])=[O:16])[CH2:11][CH:12]([CH3:13])[CH3:14])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 131713838Z-Leu-Leu-Ala-Gln-OH

Product 1

HCID 131713837H-Leu-Leu-Ala-Gln-OH

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 1.50 g of Z-Leu-Leu-Ala-Gln-OH was added 20 ml of acetic acid containing 25% of hydrogen bromide, then the mixture was stirred at a room temperature for 1 hour. To the reaction mixture was added dried ether, and solid material precipitated was collected by filtration to obtain H-Leu-Leu-Ala-Gln-OH.

Workup

  1. customprecipitated
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-2a8709566dd247ba85ebf9e2659fa3ec
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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