HRID1632388

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O

HCID13361528

未命名化合物

结构：CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713837

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713839

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1.41 Grams of Z-Ile-OSu, the above-obtained H-Leu-Leu-Ala-Gln-OH and 0.36 ml of triethylamine were dissolved in 50 ml of dimethylformamide, then the mixture was stirred at a room temperature for 20 hours. After removal of dimethylformamide by distillation, 1N-citric acid was added to the residue, and crystals being precipitated were collected by filtration and washed with hot methanol to obtain 1.17 g of Z-Ile-Leu-Leu-Ala-Gln-OH.

WORKUP

后处理

customAfter removal of dimethylformamide
distillationby distillation, 1N-citric acid
additionwas added to the residue, and crystals
custombeing precipitated
filtrationwere collected by filtration
washwashed with hot methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b90a43f7fe74b4285176cf09f77665d
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04474754
来源说明: uspto-grants-1984_10

反应 SMILES

[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[C@H:2]([C:7]([O:9]N1C(=O)CCC1=O)=O)[C@H:3]([CH2:5][CH3:6])[CH3:4].[NH2:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:46]([NH:48][C@H:49]([C:55]([OH:57])=[O:56])[CH2:50][CH2:51][C:52](=[O:54])[NH2:53])=[O:47])[CH3:45])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31].C(N(CC)CC)C>CN(C)C=O>[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])[C@H:2]([C:7]([NH:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:46]([NH:48][C@H:49]([C:55]([OH:57])=[O:56])[CH2:50][CH2:51][C:52](=[O:54])[NH2:53])=[O:47])[CH3:45])=[O:42])[CH2:37][CH:38]([CH3:39])[CH3:40])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31])=[O:9])[C@H:3]([CH2:5][CH3:6])[CH3:4]