Hydrochloric Acid → HCID 13105789, compound

HRID 1632498Notes

Reaction equation

HRID 1632498 reaction equation
S[CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[O:11][CH2:12][C:6]2=[N:5][N:4]=1.[OH-:25].[Na+].Cl.[CH3:28]O>>[CH3:28][O:25][CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[O:11][CH2:12][C:6]2=[N:5][N:4]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 13105788HCID 13105788, compound

Product 1

HCID 13105789HCID 13105789, compoundYield 92%

Procedure

To a solution of Compound 20 (0.85 g) prepared in Example 12 in methanol (100 ml) is added an aqueous solution of sodium hydroxide (10%)(4 ml), and the mixture is stirred for 3 hours, acidified with 10% hydrochloric acid, and concentrated. The residue is washed with water and chloroform to give Compound 21 (0.7 g) in 92% yield.

Workup

  1. concentrationconcentrated
  2. washThe residue is washed with water and chloroform

Sources & evidence

ORD record
ord-4ea142e20b99458dbc4429189822a4cc
Source dataset
uspto-grants-1984_10
Patent number
US04476133

Reaction notes

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