Toluene → HCID 54502383, compound

HRID 1632723Notes

Reaction equation

HRID 1632723 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4](=[N:8][O:9][CH2:10][O:11][CH3:12])[C:5]([CH3:7])=[O:6].C1(C)C=CC=CC=1.[CH3:21][N:22]([CH:24](OC)OC)[CH3:23]>C(OC(C)C)(C)C>[CH3:1][O:2][C:3](=[O:13])[C:4](=[N:8][O:9][CH2:10][O:11][CH3:12])[C:5]([CH:7]=[CH:21][N:22]([CH3:24])[CH3:23])=[O:6]

Participants

5

Reactant 3

HCID 1140TolueneHCID 78373Dimethylformamide dimethyl acetalHCID 54538753HCID 54538753, compound

Product 1

HCID 54502383HCID 54502383, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

6.4 g of 2-(methoxymethoxyimino)acetoacetic acid methyl ester in 30 of toluene are heated with 9 ml of N,N-dimethylformamidedimethylacetal for 5 hours at boiling. After cooling, the semi-crystalline residue is dissolved by heating in diisopropylether, the mixture is filtered. The precipitate obtained after cooling is filtered and dried to obtain the heading compound, m.p. 99°-100°.

Workup

  1. temperatureAfter cooling
  2. dissolutionthe semi-crystalline residue is dissolved
  3. filtrationthe mixture is filtered
  4. customThe precipitate obtained
  5. temperatureafter cooling
  6. filtrationis filtered
  7. customdried
  8. customto obtain the heading compound, m.p. 99°-100°

Sources & evidence

ORD record
ord-743c504b06754819a146442192673fd3
Source dataset
uspto-grants-1984_10
Patent number
US04477448

Reaction notes

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