Hydrochloric Acid → 1-(3,4,5-Trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazine Hydrochloride

HRID 1632975Notes

Reaction equation

HRID 1632975 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[CH:7]=[CH:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH:17]([C:19]([NH:21][CH:22]([CH3:24])[CH3:23])=[O:20])[CH3:18])[CH2:13][CH2:12]1)=[O:10]>C(O)C>[ClH:1].[CH3:31][O:30][C:26]1[CH:25]=[C:6]([CH:5]=[C:4]([O:3][CH3:2])[C:27]=1[O:28][CH3:29])[CH:7]=[CH:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH:17]([C:19]([NH:21][CH:22]([CH3:24])[CH3:23])=[O:20])[CH3:18])[CH2:13][CH2:12]1)=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 543786781-(3,4,5-Trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazin

Product 1

HCID 705055581-(3,4,5-Trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazine Hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3 ml of 15% ethanolic hydrogenchloride is added to a solution of 3.00 g of 1-(3,4,5-trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazine prepared as in Example 3 in 5 ml of ethanol, and the solvent is distilled off. Isopropanol is added to the abtained residue and the precipitates are collected by filtration.

Workup

  1. distillationthe solvent is distilled off
  2. additionIsopropanol is added to the abtained residue
  3. filtrationthe precipitates are collected by filtration

Sources & evidence

ORD record
ord-50125aaf1ec94dc5bcf46cee6f194dd8
Source dataset
uspto-grants-1984_10
Patent number
US04478838

Reaction notes

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