Hydrazine hydrate (1:1) → HCID 12582671, compound

HRID 1633046Notes

Reaction equation

HRID 1633046 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:20])[C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=3)[CH2:11][C:4]=2[CH:3]=1.O.[NH2:22][NH2:23].C([O-])(=O)/C=C/C([O-])=O>C(O)(C)C>[Cl:19][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[C:12]([N:10]1[CH2:9][CH2:8][C:5]2[N:6]=[N:7][C:2]([NH:22][NH2:23])=[CH:3][C:4]=2[CH2:11]1)=[O:20]

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 5460307Fumarate2×HCID 20441540HCID 20441540, compound

Product 1

HCID 12582671HCID 12582671, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10.8 g of 3-chloro-6-(m-chlorobenzoyl)-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine and 50 cc of hydrazine hydrate are stirred at a bath temperature of 100° for 4 hours with the addition of 25 cc of isopropanol, and the mixture is worked up to a crude base as described in Example 17, and this crude base is converted into the fumarate in a manner analogous to that described in Example 4. The fumarate of the title compound has a M.P. of 178°-180° (decomp., from absolute ethanol).

Sources & evidence

ORD record
ord-392dfe15d5a546e68fafba998efef9aa
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

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