Hydrazine hydrate (1:1) → HCID 54489213, compound

HRID 1633064Notes

Reaction equation

HRID 1633064 reaction equation
[C:1]1([O:7][C:8]([N:10]2[CH2:20][CH2:19][C:13]3[N:14]=[N:15][C:16](Cl)=[CH:17][C:12]=3[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:22][NH2:23]>>[C:1]1([O:7][C:8]([N:10]2[CH2:20][CH2:19][C:13]3[N:14]=[N:15][C:16]([NH:22][NH2:23])=[CH:17][C:12]=3[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54330500HCID 54330500, compound

Product 1

HCID 54489213HCID 54489213, compound

Procedure

A solution of 20.3 g of crude oily 3-chloro-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid phenyl ester in 100 cc of hydrazine hydrate is stirred in an oil bath of 100° for 11/2 hours. The reaction solution is concentrated in a vacuum and the residue is divided between 225 cc of chloroform and 25 c of water. The crude title compound is obtained as semicrystalline residue upon concentrating the organic phase in a vacuum.

Workup

  1. concentrationThe reaction solution is concentrated in a vacuum

Sources & evidence

ORD record
ord-aa7676a01608490abd66ba8ee5876d39
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

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